|
KMID : 0379120150430030174
|
|
Korean Journal of Mycology
2015 Volume.43 No. 3 p.174 ~ p.179
|
|
|
Antihyperglycemic α-Glucosidase Inhibitory Activity of Ethanol Extract from Neolentinus lepideus
|
|
Shin Ja-Won
Bae Sang-Min
Han Sang-Min
Lee Yun-Hae
Kim Jeong-Han
Chi Jeong-Hyun
Lee Jong-Soo
|
|
|
Abstract
|
|
|
|
For development a new anti-diabetic compound from edible mushroom, antihyperglycemic α-glucosidase inhibitory activities of Pleurotus ostreatus, Pleurotus cornucopiae, Pleurotus salmoneostramineus, Pleurotus eryngii and Neolentinus lepideus were investigated on its water and ethanol extracts. α-Glucosidase inhibitory activity of Neolentinus lepideus fruiting body showed the highest at 86.3% in the 95% ethanol extracts and water extract from Pleurotus cornucopiae was also higher at 48.5% among water extracts. Therefore, Neolentinus lepideus which showed very high α-glucosidase inhibitory activity was selected as a new anti-diabetic agent-containing mushroom and the α-glucosidase inhibitor was maximally extracted when treated with 95% ethanol at 30oC for 48 hr. The ethanol extracts from Neolentinus lepideus fruiting body showed dosage-dependent hypoglycemic action after administration to 120 min in the SD-rat and streptozotocin-induced diabetic SD-rat.
|
|
|
KEYWORD
|
|
|
Antihyperglycemic effect, α-Glucosidase inhibitor, Neolentinus lepideus
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|